Clinical and epidemiological features of acute hepatitis D viral in Republic of Moldova

Results Acute HDV in both sexes has been observed: women – 7 (26.9%), men – 19 (73.1%). Hepatitis D virus infection occurred through: surgical maneuvers in 2 patients (7.7%), dental – 5(19.2%), sexual – (7.7%), 3 (11.5%) – intrafamilial and undetermined way – 14 (53.9%). The acute onset was in 26 patients (100%), being manifested more frequently in icteric form in 21 (80.8%), than anicteric form – in 5 (19.2%). In 12 patients (46.2%), acute HDV occurs in moderate form and in 14 patients (53.8%) – in severe form. Acute HDV includes asthenic, dyspeptic and arthralgic syndrome. Biochemical investigations: bilirubin – 194.71 ± 31.67 mkmol/L, ALAT – 10.73 ± 0.79 mmol/L/h (p < 0.001), thymol – 8.74 ± 1.32 U and prothrombin index – 71.87±2.57%. Hepatomegaly 3.4 ± 0.16 cm – in 100%, splenomegaly 2.0 ± 0.18 cm – in 73.1% patients. Duration of hospitalization constituted 20.73 ± 2.66 days.